What causes mortality in autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Cardiovascular pathology and infections account for approximately 90% of deaths in patients treated with hemodialysis or peritoneal dialysis and after renal transplantation. A rare cause of mortality is in ADPKD is subarachnoid hemorrhage from intracranial aneurysms. [24]

In a retrospective, observational study of 88 patients with ADPKD who died between 1981 and 1999, Rahman et al determined that almost half of the patients died of cardiovascular problems. [25] The median age of death was 60.5 years. Causes of death included the following:

  • Cardiovascular problems - 46.6% of patients
  • Infection - 15.9% of patients, with 42% of these deaths resulting from septicemia
  • Central nervous system disorders - 11.36% of patients, with 60% of these deaths caused by cerebrovascular events
  • Uremia - 2.2% of patients
  • Other, miscellaneous causes - 11.36%

 


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