What are the risk factors for progression of autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

An early study estimated that approximately 70% of patients with ADPKD would develop renal insufficiency if they survived to age 65 years. Currently, half of all patients with ADPKD require renal replacement therapy by age 60 years. Risk factors for progression include the following:

  • PKD1 genotype
  • Large kidneys
  • Several episodes of gross hematuria [21]
  • Severe and frequent kidney infections
  • Hypertension
  • Multiple pregnancies
  • Black racial background [18]
  • Male sex

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