Which medications in the drug class Inotropic Agents are used in the treatment of Acute Kidney Injury?

Updated: Dec 24, 2020
  • Author: Biruh T Workeneh, MD, PhD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Inotropic Agents

Dopamine in small doses (eg, 1-5 mcg/kg/min) causes selective dilatation of the renal vasculature, enhancing renal perfusion. Dopamine also reduces sodium absorption, thereby decreasing the energy requirement of the damaged tubules. This enhances urine flow, which, in turn, helps to prevent tubular cast obstruction. The clinical benefit of low-dose dopamine remains uncertain.

Dopamine (Intropin)

Dopamine stimulates adrenergic and dopaminergic receptors. Its hemodynamic effect is dose dependent. Lower doses (0.5-3.0 mcg/kg/min) predominantly stimulate dopaminergic receptors, which, in turn, produce renal and mesenteric vasodilation. Higher doses produce cardiac stimulation and renal vasodilation. Potential complications of dopamine use include cardiac arrhythmias, myocardial ischemia, and intestinal ischemia.


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