What is the role of N -acetylcysteine in the treatment of acute kidney injury (AKI)?

Updated: Dec 24, 2020
  • Author: Biruh T Workeneh, MD, PhD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Another prophylactic agent, used with varying success, is oral N -acetylcysteine at a dosage of 1200 mg every 12 hours. This is administered to high-risk patients the day before a contrast study is performed and is continued the day of the procedure. N -acetylcysteine appears to provide only borderline benefit. [58] Diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and possibly angiotensin-converting enzyme (ACE) inhibitors should be withheld near the time of the procedure. [59]


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