Which medications in the drug class PO4 Scavengers are used in the treatment of Chronic Kidney Disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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PO4 Scavengers

Dietary phosphate binders promote the binding of phosphate in the gastrointestinal tract to reduce hyperphosphatemia.

Lanthanum carbonate (Fosrenol)

Lanthanum carbonate is a noncalcium, nonaluminum phosphate binder indicated for the reduction of high phosphorus levels in patients with stage 5 kidney disease. It dissociates into ions in the upper gastrointestinal tract, and these ions directly bind to dietary phosphate, forming insoluble lanthanum phosphate complexes. It therefore inhibits phosphorus absorption.

Sevelamer (Renagel, Renvela)

Sevelamer is indicated for the reduction of serum phosphorus levels in patients with CKD on hemodialysis. This agent binds dietary phosphate in the intestine, thus inhibiting its absorption. In patients on hemodialysis, sevelamer treatment results in fewer hypercalcemic episodes than does calcium acetate therapy.

Sucroferric oxyhydroxide (Velphoro)

Sucroferric oxyhydroxide is an iron-based, calcium-free phosphate binder. When it is taken with meals, dietary phosphate is adsorbed in the GI tract and eliminated in the feces. It is indicated for control of serum phosphorus levels in patients with chronic kidney disease on hemodialysis.

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