What is the role of the glomerular filtration rate (GFR) in determining medication dosages in chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

In chronic kidney disease (CKD), doses and dosing intervals of drugs that are excreted or metabolized renally should be adjusted according to the residual glomerular filtration rate (GFR). Some drugs are contraindicated in moderate to severe renal impairment because of potentially serious effects from drug or metabolite accumulation. Routine consultation of the appropriate references should be undertaken when prescribing any new drug to a patient with CKD.


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