What are the benefits of dietary sodium reduction in nondiabetic chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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A randomized, controlled trial by Slagman et al found that moderate dietary sodium reduction (approximately 2500 mg/day of Na+ or 6 g/day of NaCl) added to angiotensin-converting enzyme (ACE) inhibition compared with dual blockade (ACE inhibitor [ACEI] and angiotensin receptor blocker [ARB]) was more effective in reducing proteinuria and blood pressure in nondiabetic patients with modest CKD. Furthermore, a low-sodium diet added to dual blockade therapy yielded additional reductions in blood pressure and proteinuria [91]

Vegter et al found that among patients with CKD but without diabetes, a high dietary salt intake (> 14 g/day) interfered with the antiproteinuric effect of ACEI therapy and increased the risk for ESRD. [92] The risk was independent of blood pressure control.

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