What risk is associated with NSAIDs in chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

A study by Plantinga et al found that a great number of individuals with CKD may be unaware of their disease and thus may be at risk for further kidney injury through use of NSAIDs. [72] Persons who knew that they had CKD were less likely to use NSAIDs, suggesting that primary care physicians should be involved in communication regarding the risks of NSAIDs. [72]

However, despite the availability of guidelines and recommendations that include lists of medications that are relatively contraindicated and those that require renal dose adjustment, noncompliance with dosing guidelines and use of relatively contraindicated medications are common in patients with CKD. A cross-sectional study that included 373 adult patients with stage III/IV CKD found that 46.6% of them were prescribed at least one relatively contraindicated drug (acarbose, chlorpropamide, glyburide, nitrofurantoin or any NSAID) during the 2-year study period; 34.0% were prescribed NSAIDs. [73]


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