Which tests may be used to screen for comorbidities in the evaluation of chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

In certain cases, the following tests may be ordered as part of the evaluation of patients with CKD:

  • Serum and urine protein electrophoresis, serum and urine free light chains: Screen for a monoclonal protein possibly representing multiple myeloma

  • Antinuclear antibodies (ANA), double-stranded DNA antibody levels: Screen for systemic lupus erythematosus

  • Serum complement levels: Results may be depressed with some glomerulonephritides

  • Cytoplasmic and perinuclear pattern antineutrophil cytoplasmic antibody (C-ANCA and P-ANCA) levels: Positive findings are helpful in the diagnosis of granulomatosis with polyangiitis (Wegener granulomatosis); a positive P-ANCA result is also helpful in the diagnosis of microscopic polyangiitis

  • Anti–glomerular basement membrane (anti-GBM) antibodies: Their presence is highly suggestive of underlying Goodpasture syndrome

  • Hepatitis B and C, human immunodeficiency virus (HIV), Venereal Disease Research Laboratory (VDRL) serology: These conditions are associated with some glomerulonephritides

  • Imaging studies and consideration of bladder function studies: These evaluate for possible obstruction and other urologic abnormalities


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