What is the role of cystatin-C in determining the level of kidney function in chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Measurement of serum cystatin C levels is gaining a greater role in the estimation of kidney function. [40] Cystatin C is a small protein that is expressed in all nucleated cells, produced at a constant rate, and freely filtered by the glomerulus; it is not secreted but is instead reabsorbed by tubular epithelial cells and catabolized, so it does not return to the bloodstream. These properties make it a valuable endogenous marker of renal function. [41] A study that used cystatin C instead of creatinine to estimate glomerular filtration rate (GFR) concluded that cystatin C–based GFR equations outperform creatinine-based formulas in obese CKD patients, especially those with a body mass index (BMI) ≥35 kg/mand in obese women. [42]   


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