What are the manifestations of uremia in end-stage renal disease (ESRD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Other manifestations of uremia in end-stage renal disease (ESRD), many of which are more likely in patients who are inadequately dialyzed, include the following:

  • Pericarditis: Can be complicated by cardiac tamponade, possibly resulting in death

  • Encephalopathy: Can progress to coma and death

  • Peripheral neuropathy

  • Restless leg syndrome

  • Gastrointestinal symptoms: Anorexia, nausea, vomiting, diarrhea

  • Skin manifestations: Dry skin, pruritus, ecchymosis

  • Fatigue, increased somnolence, failure to thrive

  • Malnutrition

  • Erectile dysfunction, decreased libido, amenorrhea

  • Platelet dysfunction with tendency to bleed

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