How does uremia manifest in chronic kidney disease (CKD) stage 5?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Uremic manifestations in patients with CKD stage 5 are believed to be primarily secondary to an accumulation of multiple toxins, the full spectrum and identity of which is generally not known. Metabolic acidosis in stage 5 may manifest as protein-energy malnutrition, loss of lean body mass, and muscle weakness. Altered salt and water handling by the kidney in CKD can cause peripheral edema and, not uncommonly, pulmonary edema and hypertension.


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