Which clinically evident symptoms are associated with the different stages of chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Patients with chronic kidney disease (CKD) stages 1-3 (glomerular filtration rate [GFR] > 30 mL/min/1.73 m²) are frequently asymptomatic; in terms of possible “negative” symptoms related simply to the reduction in GFR, they do not experience clinically evident disturbances in water or electrolyte balance or endocrine/metabolic derangements.

Generally, these disturbances become clinically manifest with CKD stages 4-5 (GFR < 30 mL/min/1.73 m²). Patients with tubulointerstitial disease, cystic diseases, nephrotic syndrome, and other conditions associated with “positive” symptoms (eg, polyuria, hematuria, edema) are more likely to develop signs of disease at earlier stages.

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