What are the causes of tubulointerstitial disease?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Causes of tubulointerstitial disease include the following:

  • Drugs (eg, sulfonamides, allopurinol)
  • Infection (viral, bacterial, parasitic)
  • Sjögren syndrome
  • Tubulointerstitial nephritis and uveitis (TINU) syndrome
  • Chronic hypokalemia
  • Chronic hypercalcemia
  • Sarcoidosis
  • Multiple myeloma cast nephropathy
  • Heavy metals
  • Radiation nephritis
  • Polycystic kidneys
  • Cystinosis and other inherited diseases

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