What causes adynamic bone disease and what is its prevalence in the US?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The prevalence of adynamic bone disease in the United States has increased, and its onset before the initiation of dialysis has been reported in some cases. The pathogenesis of adynamic bone disease is not well defined, but possible contributing factors include the following:

  • High calcium load
  • Use of vitamin D sterols
  • Increasing age
  • Previous corticosteroid therapy
  • Peritoneal dialysis
  • Increased level of N-terminally truncated PTH fragments

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