What is the role of the renin-angiotensin system (RAS) in predisposing a person to chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

A number of genes have been associated with the development of ESRD. Many of these genes involve aspects of the immune system (eg, CCR3, IL1RN, IL4). [14]

Unsurprisingly, polymorphisms in genes involving the renin-angiotensin system (RAS) have also been implicated in predisposition to CKD. One study found that patients with CKD were significantly more likely to have the A2350G polymorphism in the ACE gene, which encodes the angiotensin-converting enzyme (ACE). [15] They were also more likely to have the C573T polymorphism in the AGTR1 gene, which encodes the angiotensin II type 1 receptor. [15]


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