What is the role of fibroblast growth factor 23 (FGF-23) in the risk for development or progression of chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Circulating levels of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) are affected by variants in the FGF23 gene. Isakova et al reported that elevated FGF-23 levels are an independent risk factor for ESRD in patients who have fairly well-preserved kidney function (stages 2-4) and for mortality across the scope of CKD. [11]


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