How does the National Kidney Foundation (NKF) define chronic kidney disease (CKD)?

Updated: Jul 21, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The Kidney Disease Outcomes Quality Initiative (KDOQI) of the National Kidney Foundation (NKF) established a definition and classification of CKD in 2002. [2] The KDOQI and the international guideline group Kidney Disease Improving Global Outcomes (KDIGO) subsequently updated these guidelines. [3] These guidelines have allowed better communication among physicians and have facilitated intervention at the different stages of the disease.

The guidelines define CKD as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 for at least 3 months. Whatever the underlying etiology, once the loss of nephrons and reduction of functional renal mass reaches a certain point, the remaining nephrons begin a process of irreversible sclerosis that leads to a progressive decline in the GFR. [4]

Hyperparathyroidism is one of the pathologic manifestations of CKD. See the image below.

Calciphylaxis due to secondary hyperparathyroidism.

Calciphylaxis due to secondary hyperparathyroidism Calciphylaxis due to secondary hyperparathyroidism.

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