Which antibiotics are used for the treatment of MRSA nosocomial pneumonia?

Updated: Apr 15, 2021
  • Author: Kartika Shetty, MD, FACP; Chief Editor: John L Brusch, MD, FACP  more...
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The preferred antibiotics for treatment of MRSA infections include vancomycin and linezolid. Linezolid appears to be 15% more efficacious than even adjusted-dose vancomycin. It should be considered over Vancomycin in patients with renal insufficiency and those infected with high-MIC (MIC in the upper range of sensitivity, 1.5–2 μg/mL) isolates of MRSA.The recommended antibiotics for the treatment of suspected MSSA (and not MRSA) infections include piperacillin-tazobactam, cefepime, levofloxacin, imipenem, and meropenem. When the pathogen is confirmed as MSSA, the patient should be switched to oxacillin, nafcillin, or cefazolin.

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