What is the role of proton-pump inhibitors (PPIs) in the risk of community-acquired pneumonia (CAP)?

Updated: Oct 31, 2019
  • Author: Stephanie L Baer, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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There is conflicting evidence as to the safety of using PPIs and H2 blockers. [87, 88, 89, 90] Some studies have concluded that PPI use increases the risk of pneumonia or even the risk of multidrug-resistant pathogens causing pneumonia. Other, more recent, studies find such links may have been resulted from confounding factors. [91, 89]

PPIs were associated with an increased risk of C difficile colitis compared with H2 blockers. [92]

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