How do comorbid conditions affect antimicrobial therapy selection for community-acquired pneumonia (CAP)?

Updated: Oct 31, 2019
  • Author: Stephanie L Baer, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Comorbid conditions affect a patient’s risk of contracting CAP caused by MRSA, Pseudomonas, or other antibiotic-resistant pathogens. Risks for antibiotic-resistant pathogens include hospital admission within the preceding 90 days, antibiotics in the preceding 90 days, septic shock at the time of CAP, immunosuppression, enteral tube feedings, nonambulatory status, or gastric acid suppression. MRSA risk factors include all of the prior plus hemodialysis, CHF, and a history of MRSA colonization. [55, 5] Comorbidities represent an important prognostic factor and contribute to the severity index. [47]

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