What are the outpatient treatment options for community-acquired pneumonia (CAP)?

Updated: Oct 31, 2019
  • Author: Stephanie L Baer, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Adequate therapy for CAP includes coverage for S pneumoniae and atypical bacterial pathogens. Treatment options for CAP in outpatients with no comorbidities and no risk factors for drug-resistant S pneumoniae include the following: [7]

  • Amoxicillin 1 gram PO three times a day OR
  • A macrolide (azithromycin 500 mg once and then 250 mg daily or clarithromycin 500 mg twice daily) OR
  • Doxycycline 100 mg twice daily

During influenza season, it is also reasonable to initiate oseltamivir, zanamivir, or baloxavir therapy in outpatients who present with a flulike illness and pneumonia. Macrolides should be used only in areas where pneumococcal resistance is less than 25%.

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