How is acute schistosomiasis (Katayama syndrome) differentiated from malaria?

Updated: Jun 11, 2020
  • Author: Shadab Hussain Ahmed, MD, AAHIVS, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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These symptoms mimic any acute viral, bacterial, or malarial illness. The distinguishing features from malaria include generalized urticaria, pruritic rash at the site of cercarial penetration (often the legs), eosinophilia, and lymphadenopathy. Consequently, acute illness is often missed unless schistosomiasis is suspected.

In acute schistosomiasis, patients may present with focal neurological deficits.

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