What is the regimen for TMP-SMX prophylaxis against Pneumocystis jiroveci pneumonia (PJP)?

Updated: Apr 24, 2019
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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TMP-SMX is the agent of choice for PJP prophylaxis in the absence of a contraindication. In patients who cannot tolerate TMP-SMX, other options include dapsone, dapsone plus pyrimethamine, atovaquone, and aerosolized pentamidine. Commonly used prophylactic regimens are discussed below.

For TMP-SMX, the normal dosage is one double-strength tablet (160 mg TMP to 800 mg SMX) daily. One single-strength tablet (80 mg TMP to 400 mg SMX) daily is also effective. Another alternative is one double-strength tablet 3 times per week. However, a daily-dosing regimen provides an additional benefit of cross protection against Toxoplasma gondii infection and other bacterial infections.

The use of TMP-SMX for long-term PJP prophylaxis does not seem to affect the rates of infection by drug-resistant organisms such as pneumococcus or Staphylococcus aureus. TMP-SMX resistance has been reported among some isolates of Pneumocystis. [43]

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