When is treatment response expected in Pneumocystis jiroveci pneumonia (PJP)?

Updated: Apr 24, 2019
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Answer

In patients without HIV infection, response to treatment should begin within 4-5 days. In patients infected with HIV, the treatment response typically takes longer but should occur within the first 8 days. If no response occurs within the expected time, an appropriate alternative regimen should be used. Adding additional PJP medications to a current regimen only increases the risk of adverse drug reactions without improving the likelihood of a good outcome. Up to 10% of mild-to-moderate PJP cases fail to respond to antibiotic treatment because of lack of drug efficacy.


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