What are the signs and symptoms of rabies during the prodromal period?

Updated: Jun 21, 2019
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The virus enters the CNS. The duration of this period is 2-10 days. Nonspecific symptoms and signs develop, including fevers and flulike illness. Paresthesia, pain, or intense itching at the inoculation site is pathognomonic for rabies and occurs in 30% of canine-associated rabies cases and 70% of bat-associated rabies cases during this phase; this may be the individual’s only presenting sign. Symptoms may include the following:

  • Malaise
  • Anorexia
  • Headaches
  • Fever
  • Chills
  • Pharyngitis
  • Nausea
  • Emesis
  • Diarrhea
  • Anxiety
  • Agitation
  • Insomnia
  • Depression

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