What is the role of a naproxen test in the workup of fever of unknown origin (FUO)?

Updated: May 17, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Simple, noninvasive, and inexpensive, a naproxen test may rapidly screen out infection versus neoplastic disease and significantly narrow the differential diagnoses. In this test, naproxen sodium 250 mg is given orally every 8 hours for 3 days. A sharp decline or resolution in fever within 24 hours directs the workup away from infection and suggests a neoplastic disorder.

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