What is the role of tuberculosis screening in the workup of fever of unknown origin (FUO)?

Updated: May 17, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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PPD or Mantoux screening is inexpensive and sensitive but requires placement by clinical staff and interpretation 48-72 hours later of induration size, a type IV hypersensitivity reaction (indicating prior tuberculosis exposure).

Interferon gamma release assay (IGRA) offers higher sensitivity and, where readily available and quickly processed, faster turnaround.

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