Which history may suggest a viral etiology for fever of unknown origin (FUO)?

Updated: May 17, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Acute Epstein-Barr virus (EBV) infection is easily spread, and a small percentage of adults are not immune; fever for several weeks with or without organomegaly may be the only symptom in older adults.

Acute cytomegalovirus (CMV) is similarly easy to acquire and may cause several weeks of fever in adults (reactivation is also possible, with manifestations in several organ systems).

Acute Parvovirus B19 infection can manifest with fever, arthralgias, rash, fatigue with fever being one of the most common symptoms of adults. 

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