What is the role of cidofovir in the prophylaxis against cytomegalovirus (CMV) disease?

Updated: Jul 07, 2021
  • Author: Ricardo Cedeno-Mendoza, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Cidofovir is a nucleotide that inhibits DNA replication.

It is effective against a broad range of viruses. It has been used for the treatment of refractory CMV retinitis in HIV-positive patients.

Ganciclovir resistance does not necessarily preclude the use of cidofovir.

See the Medication section for dosing.

The patient must be hydrated, and the drug must be administered with probenecid to protect the renal tubules.


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