What is the role of acyclovir in the prophylaxis against cytomegalovirus (CMV) disease?

Updated: Jul 07, 2021
  • Author: Ricardo Cedeno-Mendoza, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

High-dose valacyclovir, penciclovir, famciclovir, and acyclovir have been used for CMV prophylaxis in organ transplant recipients. The results have been mixed and depend on the transplant population.

European transplant groups are more likely to use acyclovir or valacyclovir for CMV prophylaxis than their US counterparts.

In vitro assays have shown that some strains of CMV may be susceptible to acyclovir.

Overall, acyclovir prophylaxis is not as effective as prophylaxis with ganciclovir.


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