What is the role of ganciclovir in the treatment of GI and CNS manifestations of cytomegalovirus (CMV)?

Updated: Jul 07, 2021
  • Author: Ricardo Cedeno-Mendoza, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Other uses of ganciclovir include treatment of GI disease in transplant recipients and in patients who are HIV positive. Ganciclovir has also been used to treat CMV esophagitis in both of these patient populations.

The drug is also used to treat diarrhea secondary to colitis or enteritis in patients positive for HIV after tissue biopsy and confirmation of CMV disease. Because of the high probability of CMV disease relapse (50%), maintenance therapy should be offered to most patients. [65]

Ganciclovir has also been used to treat CNS disease, including encephalitis and neuropathy, with mixed results.

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