What is the pathophysiology of cytomegalovirus (CMV) pneumonia?

Updated: Jul 07, 2021
  • Author: Ricardo Cedeno-Mendoza, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

This can be seen in immunocompetent as well as immunocompromised host, including hematopoietic stem cell transplantation (HSCT) recipients and solid organ transplant recipients. Pneumonitis is the most common manifestation of CMV infection in HSCT recipients and has a high mortality. Especially in neonates, it can lead to chronic lung disease and fibrosis. Symptoms include dry cough, shortness of breath, and fever. Imaging abnormalities include abnormal chest Xray with interstitial infiltrates as well as ground-glass opacities seen in Computed Tomography (CT) scans that could be nonspecific for CMV infections and should be correlated with serological testing, viral load, respiratory samples, and histopathology. [22]


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