What is the pathophysiology of primary cytomegalovirus (CMV) infection and viremia?

Updated: Jul 07, 2021
  • Author: Ricardo Cedeno-Mendoza, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Both replication of CMV DNA and morphogenesis of the virion capsid take place in the nucleus. Following maturation of the capsid, newly synthesized viral DNA is cleaved by an enzyme that results in packaging of linear genomic DNA. Subsequently, viral DNA-containing capsids acquire an inner layer of tegument proteins during their egress from the nucleus, including essential interactions between proteins and capsid protein, that stabilize the interaction between the capsid and the inner tegument layer of the virion. This is then transported along the cytoskeleton until the particle is enveloped. After this, the virus is released from the cell. [1]


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