What is the prevalence of cytomegalovirus (CMV) infection?

Updated: Jul 07, 2021
  • Author: Ricardo Cedeno-Mendoza, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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At least 60% of the US population has been exposed to CMV, [3] with a prevalence of more than 90% in high-risk groups (eg, male homosexuals). [4, 5] The prevailing age of infection varies worldwide. In developing countries, most infections are acquired during childhood, whereas, in developed countries, up to 50% of young adults are CMV seronegative. The incidence of CMV seropositivity rises with age and in a US-based study was reported to increase from 36% in children aged 6-11 years to 91% in individuals older than 80 years. [6] Other factors associated with CMV seropositivity include ethnicity (77% in Mexican Americans and 71% in Blacks), [7] female sex, foreign-born status, and low socioeconomic status. [7]

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