Which antibiotics do the guidelines recommend for the treatment of staphylococcal and streptococcal impetigo?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Once microorganisms are identified based on cultures, treatment is tailored to the patient’s needs. The most common organisms are staphylococcal and streptococcal strains. [2]

Impetigo (Staphylococcus and Streptococcus)

IDSA treatment recommendations include any of the following oral antibiotics [2] :

  • Dicloxacillin
  • Cephalexin
  • Erythromycin (some strains of S aureus and S pyogenes are resistant)
  • Clindamycin
  • Amoxicillin-clavulanate

In patients with a limited number of lesions, retapamulin or mupirocin ointment may be applied topically.

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