Which antibiotics are recommended in the treatment of severe streptococcal necrotizing infections in adults?

Updated: Jun 14, 2019
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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First-line agents in managing severe adult streptococcal infection are penicillin 2-4 MU IV every 4-6 hours plus  clindamycin 600-900 mg/kg IV every 8 hours. [2] For patients with severe penicillin hypersensitivity, use vancomycin, linezolid, quinupristin-dalfopristin, or daptomycin. Add an appropriate agent if a staphylococcal infection is present or suspected.

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