What are the cross-tolerance considerations in opioid equivalents?

Updated: Jan 29, 2018
  • Author: Stephen Kishner, MD, MHA; Chief Editor: Erik D Schraga, MD  more...
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See the list below:

  • Reduce opioid dose by 30-50% to accommodate for unknown cross-tolerance and titrate to goal.

  • The wide variation among individuals is multifactorial and poorly understood.

  • Incomplete cross-tolerance can lead to greater than anticipated potency in a new opioid, even in the same class of analgesic.

  • Monitor clinical response and adverse effects.

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