What are the WHO recommendations for treatment of acute brucellosis?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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For acute brucellosis in adults and children older than 8 years, the World Health Organization (WHO) guidelines recommend the following:

  • Doxycycline 100 mg PO twice daily plus rifampin 600-900 mg/day PO – Both drugs are to be given for 6 weeks; this regimen is more convenient but probably increases the risk of relapse

  • Doxycycline 100 mg PO twice daily for 6 weeks and streptomycin 1 g/day IM for 2-3 weeks – This regimen is believed to be more effective, mainly in preventing relapse; gentamicin can be used as a substitute for streptomycin and has shown equal efficacy

  • Ciprofloxacin-based regimens have shown efficacy equal to that of doxycycline-based regimens

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