What is the role of doxycycline in the treatment of brucellosis?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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For simple infections, doxycycline (100 mg PO twice daily for 6 weeks) may be the most appropriate monotherapy; however, relapse rates with such monotherapy approach 40% and as a result, rifampin (600-900 mg/day) is usually added. Fluoroquinolones (eg, ciprofloxacin) have been used as monotherapy as well but also carry a high relapse rate; adding these agents to doxycycline offers no specific advantages over other combination regimens but may be preferred in areas where resistance to rifampin is high.

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