What phenomenon my case a false-negative finding for brucellosis and how is it prevented?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
  • Print

Prozone phenomenon may occur secondary to hyperantigenemia, possibly leading to false-negative results. Accordingly, routine dilution of sera (typically beyond 1:320) is necessary to avoid this problem.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!