Which medications in the drug class Antiprotozoal Agents are used in the treatment of Babesiosis?

Updated: Apr 01, 2021
  • Author: Rachel E Strength, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antiprotozoal Agents

Protozoal infections occur throughout the world and are a major cause of morbidity and mortality in some regions. Cinchona alkaloids (eg, quinine) are effective in eradicating the parasite.

Quinine (Qualaquin)

Quinine is a schizonticide. It inhibits the growth of the parasite by increasing the pH within intracellular organelles and possibly by intercalating itself into the DNA of the parasite. It is used in combination with clindamycin.

Antiprotozoal Agents

Atovaquone is a hydroxynaphthoquinone that inhibits the mitochondrial electron transport chain by competing with ubiquinone at the ubiquinone-cytochrome-c-reductase region (complex III). Inhibition of electron transport by atovaquone results in inhibition of nucleic acid and adenosine triphosphate (ATP) synthesis in the parasites. This agent is used in combination with azithromycin.


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