Which medications in the drug class Antibiotics, Other are used in the treatment of Babesiosis?

Updated: Apr 01, 2021
  • Author: Rachel E Strength, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antibiotics, Other

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Clindamycin (Cleocin)

Clindamycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl transfer RNA (tRNA) from ribosomes, causing RNA-dependent protein synthesis to arrest. It is administered in combination with quinine.

Azithromycin (Zithromax, Zmax)

Azithromycin is one of the newer macrolide antibiotics. It inhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest. Plasma concentrations of azithromycin are very low, but tissue concentrations are much higher, making this agent valuable in the treatment of infections caused by intracellular organisms. Azithromycin has a long tissue half-life. It is administered in combination with atovaquone to treat mild-to-moderate microbial infections.

Doxycycline (Vibramycin, Doryx, Monodox)

The combination of clindamycin, doxycycline, and azithromycin was successfully used in a patient who was allergic to quinine. This agent is a bacteriostatic drug that interferes with bacterial protein and cell-wall synthesis during active multiplication by binding to the 30S ribosome. For severe cases, administer intravenously (IV); for outpatients, oral administration (PO) is preferred.


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