What is the role of antigen testing in the diagnosis of adenovirus infections?

Updated: Apr 15, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Adenoviral antigen assays include direct fluorescent antigen (DFA) and enzyme immunoassay (EIA), and are available via commercial laboratories. Typical applications for antigen assays is in the diagnosis of epidemic keratoconjunctivitis, adenoviral respiratory disease, pharyngo-conjunctivitis, and enteritis. Antigen assays are the test of choice for the detection of the fastidious adenovirus types 40 and 41 in stool samples. These enteric adenoviruses are generally “noncultivatable” and an important cause of diarrhea in infants.

Indirect immunofluorescence assays may be used for direct examination of tissue specimens and are available through commercial laboratories


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