How is insulin resistance assessed?

Updated: Jan 02, 2019
  • Author: Saranya Buppajarntham, MD; Chief Editor: Eric B Staros, MD  more...
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There are multiple methods available to assess insulin resistance, including the following:

  • Hyperinsulinemic-euglycemic glucose clamp
  • Fasting insulin
  • Homeostasis model assessment (HOMA)
  • Quantitative insulin sensitivity check index (QUICKI)
  • Kraft insulin patterns/protocol
  • Hayashi protocol

Each of these methods has its own limitations. The lack of standardization of the insulin assay procedures prevents the comparison of results between studies; as a result, studies can be compared only qualitatively. The American Diabetes Association (ADA) organized a task force to standardize insulin assays. [12]

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