What is the difference between insulin sensitivity and insulin resistance?

Updated: Jan 02, 2019
  • Author: Saranya Buppajarntham, MD; Chief Editor: Eric B Staros, MD  more...
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Insulin levels can also be used to assess Insulin resistance versus sensitivity. In insulin resistance, the ability of cells to respond to the action of insulin in transporting glucose into tissues is diminished; consequently, the resistant individual begins secreting above-normal amounts of insulin to obtain a quantitatively normal response.

Insulin resistance develops long before the appearance of disease signs. A study by Kraft found borderline diabetes in 14% of subjects with normal oral glucose tolerance tests who had been randomly referred for such evaluation. [11]

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