Answer
Answer
The Friedewald formula for estimating LDL is not valid in the following 3 conditions:
Presence of chylomicrons
Triglycerides are over 400 mg/dL, and
Presence of dysbetalipoproteinemia (type III hyperlipidemia). [4]
The above 3 situations lead to an underestimation of the LDL, and a direct level is warranted.
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