What are considerations for lipoprotein cholesterol (LDL-C) testing?

Updated: Aug 05, 2019
  • Author: Fazia Mir, MD; Chief Editor: Eric B Staros, MD  more...
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The Friedewald formula for estimating LDL is not valid in the following 3 conditions:

  1. Presence of chylomicrons

  2. Triglycerides are over 400 mg/dL, and

  3. Presence of dysbetalipoproteinemia (type III hyperlipidemia). [4]

The above 3 situations lead to an underestimation of the LDL, and a direct level is warranted.

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