What is the reference range for factor VIII?

Updated: Aug 04, 2021
  • Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP, FAMIA; Chief Editor: Eric B Staros, MD  more...
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Factor VIII (antihemophilic factor) is a key factor of the intrinsic clotting cascade. Normal hemostasis requires at least a quarter (25%) of factor VIII activity.

Symptomatic hemophiliacs usually have levels 5% of normal level. Disease is categorized as severe if the level is less than 1%, moderate if it is 1-5%, and mild if the level is more than 5%.

The reference range for factor VIII is 55-145% of normal. [1]

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