What are the treatment regimens for hepatitis C virus (HCV) genotype 2 following prior PEG-IFN and RBV treatment failure?

Updated: Dec 09, 2020
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

HCV genotype 2 PEG-IFN/ribavirin treatment-experienced patients with or without compensated cirrhosis

The recommended regimens are as follows [28] :

  • Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg) for 8 weeks (without cirrhosis) or for 12 weeks (with compensated cirrhosis)
  • Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg) for 12 weeks

Patients with genotype 2 in whom a prior treatment with sofosbuvir and ribavirin has failed

The recommended regimens are as follows:

  • Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg) for 12 weeks
  • Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg) for 12 weeks

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