How is sustained virologic response (SVR) defined in the treatment of hepatitis C virus (HCV) infection?

Updated: Dec 09, 2020
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: Michael Stuart Bronze, MD  more...
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Typically, HCV viral loads are checked during treatment at weeks 4, 8, 12, and 24, and then every 3 months after the conclusion of treatment. [1, 2, 3, 4, 5] Sustained virologic response (SVR) is defined as the absence of detectable HCV RNA on blood testing 6 months after the completion of antiviral therapy; SVR can be equated with cure. A retrospective review of HCV treatment trials noted that only 2% of patients with an undetectable HCV RNA 12 weeks after conclusion of treatment relapsed by week 24. The Food and Drug Administration now utilizes SVR12 as a primary endpoint for registrational trials evaluating therapies for HCV. [6]

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